rs2229765(A;A)
Lower IGF-1 levels; some reported associations with longevity as well as certain cancers
- Magnitude
- 2.1Worth knowing
- Repute
- Not rated
- Frequency
- 11%Average of 11 populations
- On SNPedia
- rs2229765(A;A)
- Gene
- IGF1R
Frequency
Share of people with A;A in each HapMap population.
- Han Chinese (Beijing)18%
- Mexican ancestry (Los Angeles)16%
- European ancestry (Utah)15%
- Tuscan14%
- Luhya (Kenya)14%
- African ancestry (Southwest US)12%
- Maasai (Kenya)9%
- Japanese (Tokyo)9%
- Chinese (Denver)8%
- Gujarati Indian7%
- Yoruba (Nigeria)4%
Other genotypes of rs2229765
Notes
From SNPedia
rs2229765(A;A) associated with ischemic stroke (OR = 1.641, P = 0.022) in a Chinese population After adjustment for smoking, alcohol drinking, history of hypertension, and body mass index, IGF-1R AA genotype was still significantly associated with an increased risk of IS (OR = 1.787, P = 0.029), compared with IGF-1R GG. The frequency of A-allele in advanced CRC was significantly higher then early CRC (52 vs. 37.7, OR = 1.78). According to genotype serum IGF-1 levels was significantly decreased in patients with GG genotype then patients with dominant genotypes. Our results showed a relationship between the +3179G>A polymorphism of the IGF-1R and serum IGF-1 with the progression of colorectal carcinoma.
References
Source and license
Adapted from rs2229765(A;A) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.