rs2229765

A SNP in the IGF1R gene on chromosome 15. Its most notable genotype is A;A: Lower IGF-1 levels; some reported associations with longevity as well as certain cancers

Gene
IGF1R
Location
Chr 1598,934,996 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
37%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratedLower IGF-1 levels; some reported associations with longevity as well as certain cancersWorth knowing · 2.111% of people
  2. G;GGoodNormal IGF-1 levelMinor · 1.143% of people

On SNPedia: (A;A), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 11% G;G 43%
  • European ancestry (Utah)A;A 15% G;G 30%
  • Han Chinese (Beijing)A;A 18% G;G 29%
  • Japanese (Tokyo)A;A 9% G;G 50%
  • Yoruba (Nigeria)A;A 4% G;G 54%
  • African ancestry (Southwest US)A;A 12% G;G 44%
  • Chinese (Denver)A;A 8% G;G 46%
  • Gujarati IndianA;A 7% G;G 49%
  • Luhya (Kenya)A;A 14% G;G 44%
  • Mexican ancestry (Los Angeles)A;A 16% G;G 48%
  • Maasai (Kenya)A;A 9% G;G 44%
  • TuscanA;A 14% G;G 36%

Other IGF1R SNPs

All IGF1R SNPs

Notes

From SNPedia

Show notes, about 130 words

rs2229765(A;A) associated with ischemic stroke (OR = 1.641, P = 0.022) in a Chinese population

A;A

rs2229765(A;A) associated with ischemic stroke (OR = 1.641, P = 0.022) in a Chinese population After adjustment for smoking, alcohol drinking, history of hypertension, and body mass index, IGF-1R AA genotype was still significantly associated with an increased risk of IS (OR = 1.787, P = 0.029), compared with IGF-1R GG. The frequency of A-allele in advanced CRC was significantly higher then early CRC (52 vs. 37.7, OR = 1.78). According to genotype serum IGF-1 levels was significantly decreased in patients with GG genotype then patients with dominant genotypes. Our results showed a relationship between the +3179G>A polymorphism of the IGF-1R and serum IGF-1 with the progression of colorectal carcinoma.

References

Source and license

Adapted from rs2229765 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.