rs34516635

A SNP in the IGF1R gene on chromosome 15. Its most notable genotype is A;A: Possibly increased longevity for Ashkenazi Jewish women.

Gene
IGF1R
Location
Chr 1598,908,747 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodPossibly increased longevity for Ashkenazi Jewish women.Minor · 1.5
  2. A;GGoodPossibly increased longevity for Ashkenazi Jewish women.Minor · 1.5
  3. G;GBadLess longevity for Ashkenazi Jewish women.Minor · 1.1

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other IGF1R SNPs

All IGF1R SNPs

Notes

From SNPedia

Notes

rs34516635 is one of a small number of (rare) SNPs in the IGF1R gene found in a study of 384 Ashkenazi centenarians to potentially be associated with longevity and ageing. The rs34516635(A) allele was found somewhat more frequently (p=0.02) in female centenarians than in controls. No association was found for males. Higher IGF1 levels and an average decrease in maximal lifetime height of 2.5cm were also reported to be associated with (female Ashkenazi) centenarians.

A;A

Two copies of the good version of a possible longevity gene.

Source and license

Adapted from rs34516635 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.