rs2229774

A SNP in the RARG gene on chromosome 12. Its most notable genotype is A;G: higher risk for anthracycline side-effects for childhood cancer patients

Gene
RARG
Location
Chr 1253,211,761 (GRCh38)
Highest magnitude
3.0Important
Tested on
23andMe, AncestryDNA, FamilyTreeDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GGoodcommon/normalTypical · 0.086% of people
  2. A;GMost notableBadhigher risk for anthracycline side-effects for childhood cancer patientsImportant · 3.013% of people

SNPedia records rs2229774 on the minus strand: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 86% A;G 13%
  • European ancestry (Utah)G;G 87% A;G 13%
  • Han Chinese (Beijing)G;G 100% A;G 0%
  • Japanese (Tokyo)G;G 100% A;G 0%
  • Yoruba (Nigeria)G;G 79% A;G 20%
  • African ancestry (Southwest US)G;G 93% A;G 5%
  • Chinese (Denver)G;G 97% A;G 3%
  • Gujarati IndianG;G 69% A;G 29%
  • Luhya (Kenya)G;G 70% A;G 27%
  • Mexican ancestry (Los Angeles)G;G 93% A;G 7%
  • Maasai (Kenya)G;G 76% A;G 22%
  • TuscanG;G 85% A;G 14%

Notes

From SNPedia

Notes

Genome Web news rs2229774, also known as p.Ser427Leu, in the RARG gene ups cardiotoxicity risk by roughly five times in children treated with the cancer drug anthracycline, based on a GWAS of a small number of anthracycline-treated childhood cancer patients (32 cases in the original discovery cohort and 22 in the replication population). The risk allele is the rare rs2229774(T) allele, in dbSNP orientation.

A;G

~5x higher risk of cardiotoxicity from anthracycline when used to treat childhood cancers; see discussion at rs2229774

Source and license

Adapted from rs2229774 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.