rs2267735

A SNP in the ADCYAP1R1 gene on chromosome 7. Its most notable genotype is C;C: Associated with PTSD, hyperarousal, impaired fear discrimination in traumatized females, but not males

Gene
ADCYAP1R1
Location
Chr 731,095,890 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
FamilyTreeDNA
Minor allele frequency
47%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBadAssociated with PTSD, hyperarousal, impaired fear discrimination in traumatized females, but not malesWorth knowing · 2.030% of people
  2. C;GBadOne copy of risk allele = associated with mildly increased chance of PTSD, hyperarousal, impaired fear discrimination in traumatized females, but not malesMinor · 1.049% of people
  3. G;GGoodNormal variant of snp associated with PTSD, hyperarousal in females.Typical · 0.021% of people

On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 30% C;G 49% G;G 21%
  • European ancestry (Utah)C;C 24% C;G 47% G;G 29%
  • Han Chinese (Beijing)C;C 32% C;G 48% G;G 20%
  • Japanese (Tokyo)C;C 21% C;G 54% G;G 25%
  • Yoruba (Nigeria)C;C 41% C;G 47% G;G 12%
  • African ancestry (Southwest US)C;C 39% C;G 44% G;G 18%
  • Chinese (Denver)C;C 27% C;G 49% G;G 25%
  • Gujarati IndianC;C 29% C;G 52% G;G 20%
  • Luhya (Kenya)C;C 43% C;G 43% G;G 15%
  • Mexican ancestry (Los Angeles)C;C 16% C;G 59% G;G 26%
  • Maasai (Kenya)C;C 36% C;G 47% G;G 17%
  • TuscanC;C 19% C;G 54% G;G 28%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 340 words

An SNP in a putative estrogen response element within the ADCYAP1R1 gene. C is the risk allele - associated with PTSD, hyperarousal in females. Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor. (2011). Predicts Post-traumatic stress disorder diagnoses and symptoms in females only. This may occur due to oestrogen regulation of ADCYAP1R1. Total PTSD symptoms are differentially associated with rs2267735 genotype (CC is high-risk variant) in females (p ≤ 0.001). Hyperarousal is the most robustly associated symptom with rs2267735 genotype (p = 0.0009). In a dominant/recessive model, even after controlling for childhood trauma, adult trauma, and age, genotype predicts total PTSD symptoms (p ≤ 0.001) and hyperarousal symptoms (p ≤ 0.0001). Fear discrimination (CS+ Startle minus CS− Startle) is impaired in females with rs2267735 ‘CC’ genotype. Dark enhanced startle (StartleDark – StartleLight) is significantly increased in females with rs2267735 ‘CC’ genotype.

C;C

Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor. (2011). ncbi.nlm.nih.gov The ‘CC’ allele was most robustly associated with total PTSD symptoms and among subscales, hyperarousal symptoms were the most strongly associated with rs2267735. Notably, even after controlling for childhood trauma history and adult trauma, age and race, the rs2267735 ‘CC’ allele was associated with higher levels of PTSD hyperarousal symptoms compared to ‘G’ carriers in women (p = 0.0008), but not men (p=0.51). ... Hyperarousal is the most robustly associated symptom with rs2267735 genotype (p = 0.0009). Fear discrimination (CS+ Startle minus CS− Startle) is impaired in females with rs2267735 ‘CC’ genotype. Dark enhanced startle (StartleDark – StartleLight) is significantly increased in females with rs2267735 ‘CC’ genotype.

C;G

Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor. (2011). ncbi.nlm.nih.gov

Source and license

Adapted from rs2267735 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.