rs2267735(C;C)

Associated with PTSD, hyperarousal, impaired fear discrimination in traumatized females, but not males

Magnitude
2.0Worth knowing
Repute
Bad
Frequency
30%Average of 11 populations
On SNPedia
rs2267735(C;C)
Gene
ADCYAP1R1

Frequency

Share of people with C;C in each HapMap population.

  • Luhya (Kenya)43%
  • Yoruba (Nigeria)41%
  • African ancestry (Southwest US)39%
  • Maasai (Kenya)36%
  • Han Chinese (Beijing)32%
  • Gujarati Indian29%
  • Chinese (Denver)27%
  • European ancestry (Utah)24%
  • Japanese (Tokyo)21%
  • Tuscan19%
  • Mexican ancestry (Los Angeles)16%

Other genotypes of rs2267735

  1. C;GBadOne copy of risk allele = associated with mildly increased chance of PTSD, hyperarousal, impaired fear discrimination in traumatized females, but not malesMinor · 1.049% of people
  2. G;GGoodNormal variant of snp associated with PTSD, hyperarousal in females.Typical · 0.021% of people

All about rs2267735

Notes

From SNPedia

Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor. (2011). ncbi.nlm.nih.gov The ‘CC’ allele was most robustly associated with total PTSD symptoms and among subscales, hyperarousal symptoms were the most strongly associated with rs2267735. Notably, even after controlling for childhood trauma history and adult trauma, age and race, the rs2267735 ‘CC’ allele was associated with higher levels of PTSD hyperarousal symptoms compared to ‘G’ carriers in women (p = 0.0008), but not men (p=0.51). ... Hyperarousal is the most robustly associated symptom with rs2267735 genotype (p = 0.0009). Fear discrimination (CS+ Startle minus CS− Startle) is impaired in females with rs2267735 ‘CC’ genotype. Dark enhanced startle (StartleDark – StartleLight) is significantly increased in females with rs2267735 ‘CC’ genotype.

Source and license

Adapted from rs2267735(C;C) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.