rs2268578

A SNP in the LUM gene on chromosome 12. Its most notable genotype is G;G: normal

Gene
LUM
Location
Chr 1291,107,421 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
31%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableNot ratednormalTypical · 0.044% of people
  2. A;GNot rated1.1x increased breast cancer riskTypical · 0.038% of people
  3. A;ANot rated1.9x increased breast cancer riskTypical · 0.018% of people

SNPedia records rs2268578 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageG;G 44% A;G 38% A;A 18%
  • European ancestry (Utah)G;G 80% A;G 19% A;A <1%
  • Han Chinese (Beijing)G;G 36% A;G 54% A;A 10%
  • Japanese (Tokyo)G;G 54% A;G 38% A;A 8%
  • African ancestry (Southwest US)G;G 15% A;G 47% A;A 38%
  • Chinese (Denver)G;G 43% A;G 46% A;A 11%
  • Gujarati IndianG;G 68% A;G 29% A;A 3%
  • Luhya (Kenya)G;G 11% A;G 29% A;A 60%
  • Mexican ancestry (Los Angeles)G;G 53% A;G 45% A;A 2%
  • Maasai (Kenya)G;G 16% A;G 42% A;A 43%
  • TuscanG;G 65% A;G 31% A;A 4%

Conditions, medicines and genes

Other LUM SNPs

All LUM SNPs

Notes

From SNPedia

Notes

rs2268578 is a SNP in the lumican LUM gene. Two populations of patients with breast cancer, comprising ~800 cases from the Mayo Clinic and ~4,500 cases from East Anglia, England, were analyzed for SNP associations in the decorin and lumican genes. rs2268578 was associated with breast cancer in both populations; in combined analyses, the odds ratio for rs2268578(C;T) was 1.1 (CI: 0.9-1.2) and 1.9 (CI: 1.3-2.8, p 2 df = 0.001) for homozygotes. Candidate gene study to investigate the genetic determinants of normal variation in central corneal thickness.

Source and license

Adapted from rs2268578 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.