rs3759223

A SNP in the LUM gene on chromosome 12. Its most notable genotype is A;A.

Gene
LUM
Location
Chr 1291,113,006 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
8%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodNo summary available.Typical · 0.084% of people

SNPedia records rs3759223 on the minus strand: (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 84%
  • European ancestry (Utah)A;A 98%
  • Han Chinese (Beijing)A;A 55%
  • Japanese (Tokyo)A;A 66%
  • Yoruba (Nigeria)A;A 98%
  • African ancestry (Southwest US)A;A 95%
  • Chinese (Denver)A;A 56%
  • Gujarati IndianA;A 79%
  • Luhya (Kenya)A;A 96%
  • Mexican ancestry (Los Angeles)A;A 91%
  • Maasai (Kenya)A;A 89%
  • TuscanA;A 96%

Other LUM SNPs

All LUM SNPs

Notes

From SNPedia

Notes

The association of single nucleotide polymorphisms in the 5'-regulatory region of the lumican gene with susceptibility to high myopia in Taiwan. High myopia is not associated with the SNPs in the TGIF, lumican, TGFB1, and HGF genes. The association of haplotype at the lumican gene with high myopia susceptibility in Taiwanese patients. Association of lumican gene with susceptibility to pathological myopia in the northern han ethnic chinese.

Source and license

Adapted from rs3759223 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.