rs2272127

A SNP in the IL18RAP gene on chromosome 2. Its most notable genotype is C;C: Associated with herpes and schizophrenia

Gene
IL18RAP
Location
Chr 2102,423,413 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe
Minor allele frequency
19%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBadAssociated with herpes and schizophreniaMinor · 1.569% of people
  2. C;GBadAssociated with herpes and schizophreniaMinor · 1.530% of people

On SNPedia: (C;C), (C;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageC;C 69% C;G 30%
  • European ancestry (Utah)C;C 75% C;G 25%
  • Han Chinese (Beijing)C;C 82% C;G 18%
  • Japanese (Tokyo)C;C 81% C;G 16%
  • Yoruba (Nigeria)C;C 37% C;G 60%

Conditions, medicines and genes

Other IL18RAP SNPs

All IL18RAP SNPs

Notes

From SNPedia

Notes

associations with schizophrenia and herpes rs2272127 with schizophrenia(P = 0.0007, odds ratio for C allele 1.49, 95% CI: 1.18-1.87; P = 0.03 following correction for multiple comparisons). rs2272127 was also associated with herpes simplex virus 1 (HSV1) seropositivity in cases (P = 0.04, OR for G allele 1.58, 95% CI: 1.04-2.39).

C;G

This does not indicate that you have a herpes infection. Perhaps if exposed to an infected individual, you would be more susceptible than average.

Source and license

Adapted from rs2272127 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.