rs917997
A SNP in the IL18RAP gene on chromosome 2. Its most notable genotype is C;C.
- Gene
- IL18RAP
- Location
- Chr 2102,454,108 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 28%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs917997 on the minus strand: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageC;C 53%
- European ancestry (Utah)C;C 63%
- Han Chinese (Beijing)C;C 28%
- Japanese (Tokyo)C;C 33%
- Yoruba (Nigeria)C;C 88%
- African ancestry (Southwest US)C;C 91%
- Chinese (Denver)C;C 21%
- Gujarati IndianC;C 31%
- Luhya (Kenya)C;C 71%
- Mexican ancestry (Los Angeles)C;C 29%
- Maasai (Kenya)C;C 67%
- TuscanC;C 66%
Related
Notes
From SNPedia
Show notes, about 170 words
Newly identified genetic risk variants for celiac disease related to the immune response. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Translational mini-review series on the immunogenetics of gut disease: immunogenetics of coeliac disease. Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship. Shared and distinct genetic variants in type 1 diabetes and celiac disease. Association study of the IL18RAP locus in three European populations with coeliac disease. Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions. Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions. Allelic variants of IL1R1 gene associate with severe hand osteoarthritis. An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.
Source and license
Adapted from rs917997 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.