rs917997

A SNP in the IL18RAP gene on chromosome 2. Its most notable genotype is C;C.

Gene
IL18RAP
Location
Chr 2102,454,108 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
28%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratedNo summary available.Typical · 0.053% of people

SNPedia records rs917997 on the minus strand: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 53%
  • European ancestry (Utah)C;C 63%
  • Han Chinese (Beijing)C;C 28%
  • Japanese (Tokyo)C;C 33%
  • Yoruba (Nigeria)C;C 88%
  • African ancestry (Southwest US)C;C 91%
  • Chinese (Denver)C;C 21%
  • Gujarati IndianC;C 31%
  • Luhya (Kenya)C;C 71%
  • Mexican ancestry (Los Angeles)C;C 29%
  • Maasai (Kenya)C;C 67%
  • TuscanC;C 66%

Notes

From SNPedia

Show notes, about 170 words

Newly identified genetic risk variants for celiac disease related to the immune response. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Translational mini-review series on the immunogenetics of gut disease: immunogenetics of coeliac disease. Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship. Shared and distinct genetic variants in type 1 diabetes and celiac disease. Association study of the IL18RAP locus in three European populations with coeliac disease. Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions. Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions. Allelic variants of IL1R1 gene associate with severe hand osteoarthritis. An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.

Source and license

Adapted from rs917997 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.