rs2287499
A SNP in the TP53 gene on chromosome 17. Its most notable genotype is C;C: common in clinvar
- Gene
- TP53
- Location
- Chr 177,688,850 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 34%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs2287499 on the minus strand: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageC;C 45%
- European ancestry (Utah)C;C 74%
- Han Chinese (Beijing)C;C 46%
- Japanese (Tokyo)C;C 59%
- Yoruba (Nigeria)C;C 0%
Related
Conditions, medicines and genes
Other TP53 SNPs
- rs28934578T;Tinfo@snpedia.com would like to hear from youVery important
- rs11540652C;TLi-Fraumeni Syndrome (predicted)Very important
- rs11575997C;TLi-Fraumeni Syndrome (predicted)Very important
- rs28934573C;GLi-Fraumeni Syndrome (predicted)Very important
- rs28934574C;GLi-Fraumeni Syndrome (predicted)Very important
- rs28934575C;TLi-Fraumeni Syndrome (predicted)Very important
- rs28934576C;TLi-Fraumeni Syndrome (predicted)Very important
- rs28934577A;CLi-Fraumeni Syndrome (predicted)Very important
Notes
From SNPedia
Notes
ER negative breast cancer association rs2287499, OR (95% CI) = 1.08 (0.95-1.23) for CG vs. CC and 1.60 (1.04-2.47) for GG vs. CC, p-trend = 0.01) (OR (95% CI) per variant allele: 1.42 (1.18-1.71) p-trend = 0.00009).
Source and license
Adapted from rs2287499 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.