rs2290602

A SNP in the PPARGC1A gene on chromosome 4. Its most notable genotype is G;T: 2.7x increased risk for nonalcoholic fatty liver disease

Gene
PPARGC1A
Location
Chr 423,824,109 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
Not on consumer chips

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GNot ratednormalTypical · 0.0
  2. G;TMost notableNot rated2.7x increased risk for nonalcoholic fatty liver diseaseWorth knowing · 2.0
  3. T;TNot rated2.7x increased risk for nonalcoholic fatty liver diseaseTypical · 0.0

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other PPARGC1A SNPs

All PPARGC1A SNPs

Notes

From SNPedia

Notes

rs2290602 is a SNP in the PPARGC1A gene that has been associated with nonalcoholic fatty liver disease (NAFLD). A study of 200 Japanese adults indicated an odds ratio of 2.73 (CI: 1.48-5.06, corrected p = 0.014) for the rs2290602(T) allele.7thspace.com Association between PPARGC1A polymorphisms and the occurrence of nonalcoholic fatty liver disease (NAFLD).

Source and license

Adapted from rs2290602 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.