rs2293275

A SNP in the LHCGR gene on chromosome 2. Its most notable genotype is T;T: common in clinvar

Gene
LHCGR
Location
Chr 248,694,236 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
37%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableGoodcommon in clinvarTypical · 0.023% of people
  2. C;CNot ratedNo summary available.Typical · 0.043% of people

SNPedia records rs2293275 on the minus strand: (A;A), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 23% C;C 43%
  • European ancestry (Utah)T;T 17% C;C 37%
  • Han Chinese (Beijing)T;T <1% C;C 88%
  • Japanese (Tokyo)T;T 0% C;C 88%
  • Yoruba (Nigeria)T;T 51% C;C 5%
  • African ancestry (Southwest US)T;T 46% C;C 11%
  • Chinese (Denver)T;T <1% C;C 89%
  • Gujarati IndianT;T 7% C;C 44%
  • Luhya (Kenya)T;T 60% C;C 6%
  • Mexican ancestry (Los Angeles)T;T 9% C;C 56%
  • Maasai (Kenya)T;T 46% C;C 12%
  • TuscanT;T 14% C;C 42%

Conditions, medicines and genes

Other LHCGR SNPs

All LHCGR SNPs

Notes

From SNPedia

Notes

SNP in the luteinizing hormone/chorionic gonadotropin receptor (LHCGR) gene, correlated to spermatogenetic damage and thus a risk factor for male infertility. Polymorphic variations in exon 10 of the luteinizing hormone receptor: functional consequences and associations with breast cancer. A luteinizing hormone receptor intronic variant is significantly associated with decreased risk of Alzheimer's disease in males carrying an apolipoprotein E epsilon4 allele. Genetic polymorphisms of GnRH and gonadotrophic hormone receptors affect the phenotype of polycystic ovary syndrome.

Source and license

Adapted from rs2293275 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.