rs121912518

A SNP in the LHCGR gene on chromosome 2. Its most notable genotype is C;T: Precocious male puberty (predicted)

Gene
LHCGR
Location
Chr 248,688,064 (GRCh38)
Highest magnitude
7.0Very important
Tested on
AncestryDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TGoodcommon in clinvarTypical · 0.0
  2. C;TMost notableBadPrecocious male puberty (predicted)Very important · 7.0

SNPedia records rs121912518 on the minus strand: (A;A), (A;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other LHCGR SNPs

All LHCGR SNPs

Notes

From SNPedia

Notes

aka c.1733A>G (p.Asp578Gly or D578G) The rs121912518(G) mutation is considered to be a dominantly inherited mutation leading to familial male precocious puberty, and in the US (but not in Europe), it is the most common such mutation. A 2019 article about a male inheriting such a mutation is here.

C;T

See text on main rs-page

Source and license

Adapted from rs121912518 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.