rs2297518

A SNP in the NOS2 gene on chromosome 17. Its most notable genotype is A;A.

Gene
NOS2
Location
Chr 1727,769,571 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
17%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratedNo summary available.Typical · 0.03% of people

On SNPedia: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 3%
  • European ancestry (Utah)A;A <1%
  • Han Chinese (Beijing)A;A 2%
  • Japanese (Tokyo)A;A 0%
  • Yoruba (Nigeria)A;A 0%
  • African ancestry (Southwest US)A;A 2%
  • Chinese (Denver)A;A 2%
  • Gujarati IndianA;A 5%
  • Luhya (Kenya)A;A <1%
  • Mexican ancestry (Los Angeles)A;A 2%
  • Maasai (Kenya)A;A 12%
  • TuscanA;A 6%

Notes

From SNPedia

Show notes, about 300 words

Polymorphisms in oxidative stress genes and risk for non-Hodgkin lymphoma. Polymorphism in maternal LRP8 gene is associated with fetal growth. Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. Influence of the inducible nitric oxide synthase gene (NOS2A) on inflammatory bowel disease susceptibility. Nitric oxide synthase genes and their interactions with environmental factors in Parkinson's disease. A method for detecting epistasis in genome-wide studies using case-control multi-locus association analysis. Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China. Nitric oxide synthase gene polymorphisms and prostate cancer risk. Nitric oxide synthase 2A (NOS2A) polymorphisms are not associated with invasive pneumococcal disease. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. Nitric oxide synthase 2 gene polymorphisms are associated with prostatic volume in Korean men with benign prostatic hyperplasia. Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer. Polymorphisms in genes controlling inflammation and tissue repair in rheumatoid arthritis: a case control study. Association between recurrent aphthous stomatitis and inheritance of a single-nucleotide polymorphism of the NOS2 gene encoding inducible nitric oxide synthase. Ser608Leu polymorphisms in the nitric oxide synthase-2 gene may influence urinary bladder cancer pathogenesis.

Source and license

Adapted from rs2297518 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.