rs4795067

A SNP in the NOS2 gene on chromosome 17. Its most notable genotype is G;G: slight increase in risk for psoriatic arthritis

Gene
NOS2
Location
Chr 1727,779,649 (GRCh38)
Highest magnitude
1.4Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
28%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodnormal/common in clinvarTypical · 0.052% of people
  2. A;GBadslight increase in risk for psoriatic arthritisMinor · 1.239% of people
  3. G;GMost notableBadslight increase in risk for psoriatic arthritisMinor · 1.49% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 52% A;G 39% G;G 9%
  • European ancestry (Utah)A;A 46% A;G 43% G;G 11%
  • Han Chinese (Beijing)A;A 62% A;G 33% G;G 5%
  • Japanese (Tokyo)A;A 69% A;G 29% G;G 2%
  • Yoruba (Nigeria)A;A 67% A;G 30% G;G 3%
  • African ancestry (Southwest US)A;A 39% A;G 53% G;G 9%
  • Chinese (Denver)A;A 56% A;G 38% G;G 6%
  • Gujarati IndianA;A 28% A;G 49% G;G 24%
  • Luhya (Kenya)A;A 64% A;G 34% G;G 3%
  • Mexican ancestry (Los Angeles)A;A 48% A;G 36% G;G 16%
  • Maasai (Kenya)A;A 47% A;G 42% G;G 12%
  • TuscanA;A 44% A;G 43% G;G 13%

Conditions, medicines and genes

Other NOS2 SNPs

All NOS2 SNPs

Notes

From SNPedia

Notes

reports rs4795067, with risk/non-risk alleles G/A, has an odds ratio of 1.2 (p=2e−7) for psoriatic arthritis based on a case/control study of ~2,000 patients. Nitric oxide synthase genes and their interactions with environmental factors in Parkinson's disease. Lead exposure, polymorphisms in genes related to oxidative stress, and risk of adult brain tumors.

Source and license

Adapted from rs4795067 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.