rs2298383

A SNP in the SPECC1L-ADORA2A gene on chromosome 22. Its most notable genotype is C;C: increased anxiety in response to caffeine

Gene
SPECC1L-ADORA2A
Location
Chr 2224,429,543 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
48%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratedincreased anxiety in response to caffeineWorth knowing · 2.034% of people
  2. C;TNot ratedNo summary available.Typical · 0.044% of people
  3. T;TNot ratedNo summary available.Typical · 0.022% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 34% C;T 44% T;T 22%
  • European ancestry (Utah)C;C 16% C;T 49% T;T 36%
  • Han Chinese (Beijing)C;C 21% C;T 53% T;T 26%
  • Japanese (Tokyo)C;C 18% C;T 51% T;T 31%
  • Yoruba (Nigeria)C;C 66% C;T 34% T;T 0%
  • African ancestry (Southwest US)C;C 55% C;T 34% T;T 11%
  • Chinese (Denver)C;C 26% C;T 41% T;T 33%
  • Gujarati IndianC;C 58% C;T 37% T;T 5%
  • Luhya (Kenya)C;C 44% C;T 51% T;T 6%
  • Mexican ancestry (Los Angeles)C;C 12% C;T 42% T;T 46%
  • Maasai (Kenya)C;C 39% C;T 44% T;T 17%
  • TuscanC;C 16% C;T 52% T;T 32%

Conditions, medicines and genes

Other SPECC1L-ADORA2A SNPs

All SPECC1L-ADORA2A SNPs

Notes

From SNPedia

Notes

Variation at this SNP, rs2298383, appears to influence how an individual responds to moderate levels (150mg) of caffeine.

C;C

associated with increased anxiety in response to caffeine

C;T

some anxiety from caffeine

References

Source and license

Adapted from rs2298383 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.