rs5751876

A SNP in the SPECC1L-ADORA2A gene on chromosome 22. Its most notable genotype is T;T: significantly higher anxiety levels after moderate caffeine consumption

Gene
SPECC1L-ADORA2A
Location
Chr 2224,441,333 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe
Minor allele frequency
48%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodNo summary available.Typical · 0.0
  2. C;TNot ratedNo summary available.Typical · 0.0
  3. T;TMost notableBadsignificantly higher anxiety levels after moderate caffeine consumptionWorth knowing · 2.1

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other SPECC1L-ADORA2A SNPs

All SPECC1L-ADORA2A SNPs

Notes

From SNPedia

Notes

Variation at this SNP, rs5751876, also referred to as 1976C>T or 1976T>C, appears to influence how an individual responds to moderate levels (150mg) of caffeine. T/T carriers displaying significantly increased subjective levels of anxiety after consumption. However a PharmGKB variant annotation suggests it is (C;C) genotypes who are more sensitive to caffeine. rs5751876 is not associated with how much coffee one drinks, though, nor with risk for Parkinson's disease, based on a study of 1,200 subjects. "rs2298383 shows functional potential based on in silico analyses and might therefore represent the true underlying causal variant"

Source and license

Adapted from rs5751876 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.