rs234706(A;A)

0.50 reduced risk of cleft lip / palate, 0.51 reduced risk of non-Hodgkin lymphoma. Increased responsiveness to homocysteine-lowering effects of folic acid.

Magnitude
2.5Worth knowing
Repute
Good
Frequency
5%Average of 11 populations
On SNPedia
rs234706(A;A)
Gene
CBS

Frequency

Share of people with A;A in each HapMap population.

  • Gujarati Indian11%
  • African ancestry (Southwest US)11%
  • European ancestry (Utah)10%
  • Tuscan9%
  • Yoruba (Nigeria)7%
  • Luhya (Kenya)4%
  • Maasai (Kenya)3%
  • Mexican ancestry (Los Angeles)2%
  • Han Chinese (Beijing)0%
  • Japanese (Tokyo)0%
  • Chinese (Denver)0%

Other genotypes of rs234706

  1. A;GGood0.94 reduced risk of cleft lip / palateMinor · 1.130% of people
  2. G;GGoodcommon in clinvarTypical · 0.065% of people

All about rs234706

Notes

From SNPedia

We found a reduced risk of CL/P with mothers who carried the CBS C699T variant (rs234706); relative risk was 0.94 with one copy of the T allele (95% CI 0.63-1.4) and 0.50 (95% CI 0.26-0.96) with two copies (P = 0.008). PMID 18203168 A significantly reduced risk of NHL was associated with the homozygous TT genotype in CBS (rs234706, Ex9+33C>T) (OR = 0.51, 95 % CI 0.31-0.84) PMID 23913011

References

Source and license

Adapted from rs234706(A;A) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.