rs234706(A;G)

0.94 reduced risk of cleft lip / palate

Magnitude
1.1Minor
Repute
Good
Frequency
30%Average of 11 populations
On SNPedia
rs234706(A;G)
Gene
CBS

Frequency

Share of people with A;G in each HapMap population.

  • European ancestry (Utah)48%
  • Luhya (Kenya)44%
  • Tuscan43%
  • Gujarati Indian43%
  • Maasai (Kenya)39%
  • African ancestry (Southwest US)39%
  • Yoruba (Nigeria)33%
  • Mexican ancestry (Los Angeles)26%
  • Japanese (Tokyo)6%
  • Chinese (Denver)5%
  • Han Chinese (Beijing)4%

Other genotypes of rs234706

  1. A;AMost notableGood0.50 reduced risk of cleft lip / palate, 0.51 reduced risk of non-Hodgkin lymphoma. Increased responsiveness to homocysteine-lowering effects of folic acid.Worth knowing · 2.55% of people
  2. G;GGoodcommon in clinvarTypical · 0.065% of people

All about rs234706

Notes

From SNPedia

We found a reduced risk of CL/P with mothers who carried the CBS C699T variant (rs234706); relative risk was 0.94 with one copy of the T allele (95% CI 0.63-1.4) and 0.50 (95% CI 0.26-0.96) with two copies (P = 0.008). PMID 18203168

Source and license

Adapted from rs234706(A;G) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.