rs235756

A SNP in the BMP2 gene on chromosome 20. Its most notable genotype is G;G: normal

Gene
BMP2
Location
Chr 206,786,464 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
32%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableNot ratednormalTypical · 0.015% of people
  2. A;GNot ratedhigher transferrin levels if rs1800562(A;A)Typical · 0.041% of people
  3. A;ANot ratedhigher transferrin levels if rs1800562(A;A)Typical · 0.044% of people

SNPedia records rs235756 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 15% A;G 41% A;A 44%
  • European ancestry (Utah)G;G 14% A;G 44% A;A 42%
  • Han Chinese (Beijing)G;G 3% A;G 23% A;A 74%
  • Japanese (Tokyo)G;G 2% A;G 15% A;A 83%
  • Yoruba (Nigeria)G;G 22% A;G 54% A;A 25%
  • African ancestry (Southwest US)G;G 29% A;G 45% A;A 27%
  • Chinese (Denver)G;G 5% A;G 27% A;A 69%
  • Gujarati IndianG;G 17% A;G 39% A;A 45%
  • Luhya (Kenya)G;G 20% A;G 52% A;A 28%
  • Mexican ancestry (Los Angeles)G;G 16% A;G 47% A;A 38%
  • Maasai (Kenya)G;G 26% A;G 51% A;A 23%
  • TuscanG;G 16% A;G 50% A;A 34%

Conditions, medicines and genes

Other BMP2 SNPs

All BMP2 SNPs

Notes

From SNPedia

Notes

rs235756, a relatively common SNP in the BMP2 gene, has been associated with higher serum transferrin levels - and presumably therefore higher risk for developing hemochromatosis - in the rare individuals who are rs1800562(A;A) homozygotes, i.e. those known as C282Y homozygotes.

Source and license

Adapted from rs235756 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.