rs3178250

A SNP in the BMP2 gene on chromosome 20. Its most notable genotype is C;C: Lower otosclerosis risk

Gene
BMP2
Location
Chr 206,779,554 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
26%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodLower otosclerosis riskWorth knowing · 2.09% of people

On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 9%
  • European ancestry (Utah)C;C 4%
  • Han Chinese (Beijing)C;C 19%
  • Japanese (Tokyo)C;C 16%
  • Yoruba (Nigeria)C;C 3%
  • African ancestry (Southwest US)C;C 5%
  • Chinese (Denver)C;C 28%
  • Gujarati IndianC;C 9%
  • Luhya (Kenya)C;C 4%
  • Mexican ancestry (Los Angeles)C;C 0%
  • Maasai (Kenya)C;C 7%
  • TuscanC;C 6%

Other BMP2 SNPs

All BMP2 SNPs

Notes

From SNPedia

Notes

rs3178250(C;C)protected against otosclerosis (combined populations: p = 2.2 x 10(-4); OR = 2.027; 95% CI = 1.380-2.979

Source and license

Adapted from rs3178250 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.