rs2486758
A SNP in the CYP17A1 gene on chromosome 10. Its most notable genotype is C;C: Slightly higher prostate cancer risk; poorer response to AA/P treatment
- Gene
- CYP17A1
- Location
- Chr 10102,837,723 (GRCh38)
- Highest magnitude
- 2.2Worth knowing
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 19%
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CMost notableBadSlightly higher prostate cancer risk; poorer response to AA/P treatment
- C;TBadSlightly higher prostate cancer risk; poorer response to AA/P treatment
- T;TGoodSlightly lower prostate cancer risk; better response to AA/P treatment
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageC;C 5% C;T 26% T;T 70%
- European ancestry (Utah)C;C 5% C;T 34% T;T 61%
- Han Chinese (Beijing)C;C 3% C;T 33% T;T 64%
- Japanese (Tokyo)C;C 15% C;T 39% T;T 46%
- Yoruba (Nigeria)C;C 0% C;T 8% T;T 92%
- African ancestry (Southwest US)C;C 0% C;T 12% T;T 88%
- Chinese (Denver)C;C 5% C;T 28% T;T 67%
- Gujarati IndianC;C 8% C;T 36% T;T 56%
- Luhya (Kenya)C;C <1% C;T 6% T;T 93%
- Mexican ancestry (Los Angeles)C;C 9% C;T 38% T;T 53%
- Maasai (Kenya)C;C <1% C;T 14% T;T 85%
- TuscanC;C 4% C;T 33% T;T 63%
Related
Conditions, medicines and genes
Other CYP17A1 SNPs
- rs104894135G;GComplete combined 17-alpha-hydroxylase/17,20-lyase deficiencyVery important
- rs104894138A;AComplete combined 17-alpha-hydroxylase/17,20-lyase deficiencyVery important
- rs104894141T;TComplete combined 17-alpha-hydroxylase/17,20-lyase deficiencyVery important
- rs104894142A;AComplete combined 17-alpha-hydroxylase/17,20-lyase deficiencyVery important
- rs104894143G;GComplete combined 17-alpha-hydroxylase/17,20-lyase deficiencyVery important
- rs104894144C;CComplete combined 17-alpha-hydroxylase/17,20-lyase deficiencyVery important
- rs104894145A;AComplete combined 17-alpha-hydroxylase/17,20-lyase deficiencyVery important
- rs104894146C;CComplete combined 17-alpha-hydroxylase/17,20-lyase deficiencyVery important
Notes
From SNPedia
Notes
rs2486758 represents a variant in the CYP17A1 gene located in the intergenic region 5' to, or perhaps in, the promoter region. The minor allele, rs2486758(C), has been associated with the following: * Slightly increased risk for prostate cancer, including in a meta-analysis * Poorer response to treatment of metastatic castration-resistant prostate cancer by AA/P (abiraterone acetate plus prednisone).
C;C
see discussion at rs2486758
C;T
see discussion at rs2486758
T;T
see discussion at rs2486758
Source and license
Adapted from rs2486758 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.