rs267607048

A SNP in the SHOC2 gene on chromosome 10. Its most notable genotype is A;G: Noonan-like syndrome with loose anagen hair

Gene
SHOC2
Location
Chr 10110,964,362 (GRCh38)
Highest magnitude
7.0Very important
Tested on
23andMe, AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodcommon in clinvarTypical · 0.0
  2. A;GMost notableBadNoonan-like syndrome with loose anagen hairVery important · 7.0

On SNPedia: (A;A), (A;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other SHOC2 SNPs

All SHOC2 SNPs

Notes

From SNPedia

Notes

aka c.4A>G (p.Ser2Gly) The rs267607048(G) variant is classified by an expert panel review in ClinVar as a dominant mutation leading to a disorder called Noonan-like syndrome with loose anagen hair.

A;G

see discussion and links via main rs-page

Source and license

Adapted from rs267607048 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.