rs267607129

A SNP in the TNNI3 gene on chromosome 19. Its most notable genotype is C;G: Familial Hypertrophic Cardiomyopathy

Gene
TNNI3
Location
Chr 1955,151,912 (GRCh38)
Highest magnitude
6.2Very important
Tested on
AncestryDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GGoodcommon in clinvarTypical · 0.0
  2. C;GMost notableBadFamilial Hypertrophic CardiomyopathyVery important · 6.2
  3. C;CBadDilated cardiomyopathy, type 1FFVery important · 6.0

SNPedia records rs267607129 on the minus strand: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other TNNI3 SNPs

All TNNI3 SNPs

Notes

From SNPedia

Notes

rs267607129, also known as c.555C>G, p.Asn185Lys and N185K, represents a rare mutation in the TNNI3 gene on chromosome 19. A single copy of the rare rs267607129(G) allele is reported to lead to dilated cardiomyopathy, type 1FF. For more information, see OMIM 191044.0013. This mutation is referred to as i5048706 by 23andMe. Be aware of the ambiguous strand flip since this is a C/G SNP, reported on the minus strand in SNPedia and dbSNP but on the plus strand in 23andMe.

C;C

See discussion at rs267607129

Source and license

Adapted from rs267607129 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.