rs267607130

A SNP in the TNNI3 gene on chromosome 19. Its most notable genotype is G;T: Familial Hypertrophic Cardiomyopathy

Gene
TNNI3
Location
Chr 1955,157,052 (GRCh38)
Highest magnitude
6.2Very important
Tested on
AncestryDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TGoodcommon in clinvarTypical · 0.0
  2. G;TMost notableBadFamilial Hypertrophic CardiomyopathyVery important · 6.2
  3. G;GBadDilated cardiomyopathy, type 1FFVery important · 6.0

SNPedia records rs267607130 on the minus strand: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other TNNI3 SNPs

All TNNI3 SNPs

Notes

From SNPedia

Notes

rs267607130, also known as c.106A>C, p.Lys36Gln and K36Q, represents a rare mutation in the TNNI3 gene on chromosome 19. A single copy of the rare rs267607130(C) allele is reported to lead to dilated cardiomyopathy, type 1FF. For more information, see OMIM 191044.0012. This mutation is referred to as i5007736 by 23andMe.

G;G

See discussion at rs267607130

Source and license

Adapted from rs267607130 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.