rs267607815
A SNP in the MLH1 gene on chromosome 3. Its most notable genotype is A;T: Lynch syndrome, pathogenic mutation
- Gene
- MLH1
- Location
- Chr 337,025,635 (GRCh38)
- Highest magnitude
- 6.0Very important
- Tested on
- AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- A;TMost notableBadLynch syndrome, pathogenic mutation
- A;GBadLynch syndrome, pathogenic mutation
- A;CBadLynch syndrome, pathogenic mutation
- A;AGoodcommon in clinvar
SNPedia records rs267607815 on the minus strand: (A;T), (C;T), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other MLH1 SNPs
- rs11541859G;TLynch syndrome, pathogenic mutationVery important
- rs35001569A;TLynch syndrome, pathogenic mutationVery important
- rs41542214C;TLynch syndromeVery important
- rs63749795C;TLynch syndrome, pathogenic mutationVery important
- rs63749804-;CLynch syndrome, pathogenic mutationVery important
- rs63749813-;GALynch syndrome, pathogenic mutationVery important
- rs63749816-;CLynch syndrome, pathogenic mutationVery important
- rs63749818A;CLynch syndrome, pathogenic mutationVery important
Notes
From SNPedia
Notes
aka c.1039-2A>C, c.1039-2A>G and c.1039-2A>T; all three of these MLH1 gene mutations are considered in ClinVar to be likely pathogenic for Lynch syndrome
Source and license
Adapted from rs267607815 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.