rs2735839

A SNP in the KLK3 gene on chromosome 19. Its most notable genotype is A;A: in prostrate cancer patients, this is statistically associated with a somewhat more aggressive cancer

Gene
KLK3
Location
Chr 1950,861,367 (GRCh38)
Highest magnitude
1.8Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
29%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBadin prostrate cancer patients, this is statistically associated with a somewhat more aggressive cancerMinor · 1.811% of people
  2. A;GBadin prostrate cancer patients, this is statistically associated with a somewhat more aggressive cancerMinor · 1.642% of people
  3. G;GNot ratedNo summary available.Typical · 0.047% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 11% A;G 42% G;G 47%
  • European ancestry (Utah)A;A 3% A;G 22% G;G 75%
  • Han Chinese (Beijing)A;A 16% A;G 46% G;G 38%
  • Japanese (Tokyo)A;A 19% A;G 44% G;G 37%
  • Yoruba (Nigeria)A;A 14% A;G 48% G;G 37%
  • African ancestry (Southwest US)A;A 9% A;G 41% G;G 50%
  • Chinese (Denver)A;A 16% A;G 52% G;G 32%
  • Gujarati IndianA;A 8% A;G 43% G;G 50%
  • Luhya (Kenya)A;A 16% A;G 48% G;G 36%
  • Mexican ancestry (Los Angeles)A;A 3% A;G 40% G;G 57%
  • Maasai (Kenya)A;A 18% A;G 49% G;G 33%
  • TuscanA;A 2% A;G 27% G;G 71%

Conditions, medicines and genes

Other KLK3 SNPs

All KLK3 SNPs

Notes

From SNPedia

Show notes, about 230 words

A study of ~1,800 Caucasian prostate cancer patients concludes that the rs2735839(A) allele is associated with aggressive prostate cancer in general, and more specifically, in Gleason score 7 patients, it is more often associated with being GS 4 + 3 rather than GS 3 + 4 (odd ratio 1.85, CI: 1.31-2.61). cancer-genetics these snps influence genetic risk for prostate cancer *the haplotype rs6983267 rs1016343 rs4242384 *rs7501939 *rs1859962 *rs2660753 *rs9364554 *rs6465657 *rs10993994 *rs7931342 *rs2735839 *rs5945619 *rs10993994 Genotyping 13 SNPs (including this one) in 1,308 Caucasian prostate cancer patients led to the conclusion that while none of the SNP associations were as significant as having a first-degree family history of the disease, they did replicate. And in fact, for rs2735839, the risk estimate varied by family history. Prostate-Specific Antigen

A;A

Based on a He et al. 2014 Clin Can Res article, the rs2735839(A) allele is associated with more aggressive prostate cancer in general, and Gleason score 7 patients, with increased risk of being GS 4 + 3 compared to GS 3 + 4 (odds ratio 1.85, CI: 1.31–2.61).

A;G

Based on a He et al. 2014 Clin Can Res article, the rs2735839(A) allele is associated with more aggressive prostate cancer in general, and Gleason score 7 patients, with increased risk of being GS 4 + 3 compared to GS 3 + 4 (odds ratio 1.85, CI: 1.31–2.61).

Source and license

Adapted from rs2735839 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.