rs281875321
A SNP in the SMAD4 gene on chromosome 18. Its most notable genotype is C;T: Juvenile polyposis syndrome
- Gene
- SMAD4
- Location
- Chr 1851,078,307 (GRCh38)
- Highest magnitude
- 5.1Very important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;TMost notableBadJuvenile polyposis syndrome
- T;TGoodcommon in clinvar
On SNPedia: (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other SMAD4 SNPs
- rs80338963C;GJuvenile polyposis syndromeVery important
- rs80338965-;CAGAJuvenile polyposis syndromeVery important
- rs121912581A;GNo summary available.Very important
- rs281875320A;GJuvenile polyposis syndromeVery important
- rs281875322A;GJuvenile polyposis syndromeVery important
- rs281875324A;GJuvenile polyposis syndromeVery important
- rs377767328-;TCJuvenile polyposis syndromeVery important
- rs377767331C;GJuvenile polyposis syndromeVery important
Source and license
Adapted from rs281875321 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.