rs2834167

A SNP in the IL10RB gene on chromosome 21. Its most notable genotype is A;A: 2.67x increased risk for systemic sclerosis

Gene
IL10RB
Location
Chr 2133,268,483 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
34%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad2.67x increased risk for systemic sclerosisWorth knowing · 2.151% of people
  2. A;GNot ratednormalTypical · 0.035% of people
  3. G;GNot ratednormalTypical · 0.015% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 51% A;G 35% G;G 15%
  • European ancestry (Utah)A;A 53% A;G 42% G;G 5%
  • Han Chinese (Beijing)A;A 20% A;G 44% G;G 36%
  • Japanese (Tokyo)A;A 25% A;G 53% G;G 22%
  • Yoruba (Nigeria)A;A 82% A;G 17% G;G <1%
  • African ancestry (Southwest US)A;A 77% A;G 21% G;G 2%
  • Chinese (Denver)A;A 25% A;G 39% G;G 36%
  • Gujarati IndianA;A 33% A;G 50% G;G 18%
  • Luhya (Kenya)A;A 86% A;G 12% G;G 2%
  • Mexican ancestry (Los Angeles)A;A 21% A;G 48% G;G 31%
  • Maasai (Kenya)A;A 77% A;G 23% G;G 0%
  • TuscanA;A 59% A;G 32% G;G 9%

Conditions, medicines and genes

Other IL10RB SNPs

All IL10RB SNPs

Notes

From SNPedia

Show notes, about 150 words

rs2834167 is a SNP in the interleukin-10 receptor 2 IL10RB gene. In a study of Japanese patients, rs2834167(A;A) individuals were at increased risk for diffuse cutaneous systemic sclerosis (odds ratio 2.67, p = 0.0018).

A;A

IL-10RB rs2834167 (A/G) polymorphism is associated with the susceptibility to systemic lupus erythematosus: evidence from a study in Chinese Han population. We found that the frequency of A allele for rs2834167 in patients (44.53 %) was significantly higher than in controls (40.16 %) (χ (2) = 5.24, P = 0.022). Allele A was associated with a 1.196-fold (95 % confidence interval (CI), 1.026-1.394) greater risk for the occurrence of SLE compared with the G allele. And both genotypes AG and AA were associated with the susceptibility to SLE as compared with the GG genotype (AG versus GG, odds ratio (OR) = 1.332; 95 %CI, 1.047-1.696; AA versus GG, OR = 1.373; 95 %CI, 1.004-1.878).

References

Source and license

Adapted from rs2834167 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.