rs28357092
A SNP in the FCN3 gene on chromosome 1. Its most notable genotype is -;-: possible immunodeficiency
- Gene
- FCN3
- Location
- Chr 127,373,182 (GRCh38)
- Highest magnitude
- 4.0Very important
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 2%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- -;-Most notableBadpossible immunodeficiency
- -;GBadcarrier of one allele for possible 2-allele immunodeficiency mutation
- G;GGoodcommon in complete genomics
- D;DBadpossible immunodeficiency
- D;IBadcarrier of one allele for possible 2-allele immunodeficiency mutation
- I;IGoodNo summary available.
SNPedia records rs28357092 on the minus strand: (-;-), (-;C), (C;C), (D;D), (D;I), (I;I). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Notes
From SNPedia
Show notes, about 130 words
This SNP has been merged into rs532781899, but since the OMIM and 23andMe links are to this SNP, for the time being it is being retained (until OMIM and 23andMe update their records to reflect the merge). A single publication based on a single patient concludes that carrying two copies of the deletion form of rs28357092 leads to immunodeficiency due to ficolin-3 deficiency.. To date there does not appear to be another publication replicating this finding, nor are there functional studies in mice or in vitro, and so the finding should probably be considered preliminary.
-;-
see discussion at rs28357092 and rs532781899
-;G
see discussion at rs28357092 and rs532781899
D;D
see discussion at rs28357092 and rs532781899
D;I
see discussion at rs28357092 and rs532781899
Source and license
Adapted from rs28357092 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.