rs532781899
A SNP in the FCN3 gene on chromosome 1. Its most notable genotype is -;-: possible immunodeficiency
- Gene
- FCN3
- Location
- Chr 127,373,180 (GRCh38)
- Highest magnitude
- 4.0Very important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- -;-Most notableBadpossible immunodeficiency
- -;GBadcarrier of one allele for possible 2-allele immunodeficiency mutation
- G;GGoodcommon in clinvar
On SNPedia: (-;-), (-;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Notes
From SNPedia
Notes
This SNP was more commonly known formerly rs28357092, which is how both OMIM and 23andMe refer to it. A single publication based on a single patient concludes that carrying two copies of the deletion form of rs532781899 leads to immunodeficiency due to ficolin-3 deficiency.. To date there does not appear to be another publication replicating this finding, nor are there functional studies in mice or in vitro, and so the finding should probably be considered preliminary.
-;-
see discussion at rs28357092 and rs532781899
-;G
see discussion at rs28357092 and rs532781899
Source and license
Adapted from rs532781899 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.