rs2854128
A SNP on chromosome MT. Its most notable genotype is A;A: G2706A+, probably MT-Haplogroup H.
- Gene
- None listed
- Location
- Chr MT2,706 (GRCh38)
- Highest magnitude
- 1.0Minor
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 17%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (A;A), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageA;A 11% G;G 88%
- European ancestry (Utah)A;A 45% G;G 53%
- Han Chinese (Beijing)A;A 0% G;G 100%
- Japanese (Tokyo)A;A 0% G;G 100%
- Yoruba (Nigeria)A;A 0% G;G 100%
Related
Genosets
Genosets combine several genotypes. Twofold checks them in your report.
Notes
From SNPedia
Show notes, about 170 words
More commonly known as G2706A, this is one of the two ancestral mitochondrial mutations that define Mitochondrial Haplogroup H. However, this is also a mutation which changes both the RNA of the mitochondrial ribosome (potentially changing its shape and function) and the protective protein humanin which is encoded from the RNA of the ribosome itself.
A;A
One of the 2 ancestral mitochondrial mutations needed for mitochondrial Haplogroup H. This is a non-synonymous mutation in the mitochondrial ribosome, and possibly in the neuroprotective protein humanin. Haplogroup H has been associated with increased risk of age-related neurological diseases, suggesting that this mutation (or some other) may slightly reduce the effectiveness of mitochondria or humanin.
G;G
Not mitochondrial haplogroup H. The original non-mutated version.
Source and license
Adapted from rs2854128 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.