rs288326
A SNP in the FRZB gene on chromosome 2. Its most notable genotype is G;G: common in complete genomics
- Gene
- FRZB
- Location
- Chr 2182,838,608 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 5%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 9 HapMap populations.
- AverageG;G 92%
- European ancestry (Utah)G;G 77%
- Han Chinese (Beijing)G;G 100%
- Japanese (Tokyo)G;G 100%
- Yoruba (Nigeria)G;G 99%
- Gujarati IndianG;G 96%
- Luhya (Kenya)G;G 99%
- Mexican ancestry (Los Angeles)G;G 90%
- Maasai (Kenya)G;G 97%
- TuscanG;G 75%
Related
Notes
From SNPedia
Show notes, about 120 words
Meta-analysis of 14 studies did not support a significant association between rs288326 and osteoarthritis. Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. Further evidence of the role of frizzled-related protein gene polymorphisms in osteoarthritis. Power of multifactor dimensionality reduction and penalized logistic regression for detecting gene-gene interaction in a case-control study. No association of the polymorphisms of the frizzled-related protein gene with peak bone mineral density in Chinese nuclear families. Variant alleles of the Wnt antagonist FRZB are determinants of hip shape and modify the relationship between hip shape and osteoarthritis.
Source and license
Adapted from rs288326 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.