rs7775

A SNP in the FRZB gene on chromosome 2. Its most notable genotype is G;G.

Gene
FRZB
Location
Chr 2182,834,857 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
11%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableNot ratedNo summary available.Typical · 0.082% of people
  2. C;CNot ratedNo summary available.Typical · 0.02% of people

SNPedia records rs7775 on the minus strand: (C;C), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageG;G 82% C;C 2%
  • European ancestry (Utah)G;G 91% C;C 0%
  • Han Chinese (Beijing)G;G 98% C;C 0%
  • Japanese (Tokyo)G;G 100% C;C 0%
  • Yoruba (Nigeria)G;G 41% C;C 6%

Conditions, medicines and genes

Other FRZB SNPs

All FRZB SNPs

Notes

From SNPedia

Show notes, about 140 words

rs7775 (R324G) osteoarthritis at multiple joints (p = 0.07), particularly in the hip in women associated with osteoarthritis of the hip in females This is an arg324-to-gly (R324G) substitution Meta-analysis of 14 studies did not support a significant association between rs7775 and osteoarthritis. Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. Genetic variation in candidate osteoporosis genes, bone mineral density, and fracture risk: the study of osteoporotic fractures. No association of the polymorphisms of the frizzled-related protein gene with peak bone mineral density in Chinese nuclear families. Variant alleles of the Wnt antagonist FRZB are determinants of hip shape and modify the relationship between hip shape and osteoarthritis.

C;C

appears to be common on the 23andMe platform

Source and license

Adapted from rs7775 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.