rs28933390

A SNP in the BCHE gene on chromosome 3. Its most notable genotype is A;A: Pseudocholinesterase Deficiency

Gene
BCHE
Location
Chr 3165,829,781 (GRCh38)
Highest magnitude
4.0Very important
Tested on
23andMe, AncestryDNA
Minor allele frequency
<1%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;CGoodcommon in clinvarTypical · 0.0
  2. A;CBadPossible pseudocholinesterase deficiency carrierImportant · 3.0
  3. A;AMost notableBadPseudocholinesterase DeficiencyVery important · 4.0

SNPedia records rs28933390 on the minus strand: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other BCHE SNPs

All BCHE SNPs

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Notes

(T;T) abolishes catalytic activity in BCHE according to annerwright Pseudocholinesterase Deficiency

A;C

Variant of uncertain significance; definitely unaffected in absence of a second BCHE gene mutation; see links via main rs-page

Source and license

Adapted from rs28933390 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.