rs28937316
A SNP in the SCN5A gene on chromosome 3. Its most notable genotype is T;T: long QT syndrome
- Gene
- SCN5A
- Location
- Chr 338,551,441 (GRCh38)
- Highest magnitude
- 5.0Very important
- Tested on
- 23andMe, AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- T;TMost notableBadlong QT syndrome
- C;TBadRomano-Ward Long QT Syndrome
- C;CGoodcommon in clinvar
SNPedia records rs28937316 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other SCN5A SNPs
- rs137854606A;CBrugada SyndromeVery important
- rs137854612C;TBrugada SyndromeVery important
- rs137854615A;GBrugada SyndromeVery important
- rs137854620C;TBrugada SyndromeVery important
- rs199473058C;TBrugada SyndromeVery important
- rs199473083C;TBrugada SyndromeVery important
- rs199473225A;GBrugada SyndromeVery important
- rs199473249C;GBrugada SyndromeVery important
Notes
From SNPedia
Notes
rs28937316, also known as Arg1644His or R1664H, is a SNP in the cardiac sodium channel SCN5A gene on chromosome 3. Acting in a dominant manner, one copy of a rs28937316(A) allele is considered causative for long QT syndrome 3. This variant meets the criteria published in 2013 by the ACMG regarding incidental findings in exome or genome sequencing, as a variant that they do recommend informing a patient about.
T;T
The rare rs28937316(A) allele is reported to be associated with long QT syndrome.
Source and license
Adapted from rs28937316 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.