rs3026785

A SNP in the RET gene on chromosome 10. Its most notable genotype is C;C: may be protective against Hirschsprung disease

Gene
RET
Location
Chr 1043,130,238 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
3%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratedmay be protective against Hirschsprung diseaseTypical · 0.0<1% of people
  2. C;TNot ratedmay be protective against Hirschsprung diseaseTypical · 0.08% of people
  3. T;TGoodnormalTypical · 0.092% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C <1% C;T 8% T;T 92%
  • European ancestry (Utah)C;C 0% C;T 11% T;T 90%
  • Han Chinese (Beijing)C;C 0% C;T 0% T;T 100%
  • Japanese (Tokyo)C;C 0% C;T 6% T;T 94%
  • Yoruba (Nigeria)C;C 0% C;T 6% T;T 94%
  • African ancestry (Southwest US)C;C 0% C;T 4% T;T 97%
  • Chinese (Denver)C;C 0% C;T 3% T;T 97%
  • Gujarati IndianC;C 0% C;T 25% T;T 75%
  • Luhya (Kenya)C;C 0% C;T 7% T;T 93%
  • Mexican ancestry (Los Angeles)C;C 2% C;T 7% T;T 91%
  • Maasai (Kenya)C;C <1% C;T 7% T;T 92%
  • TuscanC;C 0% C;T 14% T;T 86%

Conditions, medicines and genes

Other RET SNPs

All RET SNPs

Notes

From SNPedia

Notes

Associated with protection from Hirschsprung disease See OMIM 164761.0052

Source and license

Adapted from rs3026785 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.