rs307377

A SNP in the TAS1R3 gene on chromosome 1. Its most notable genotype is T;T: extra tasting ability?

Gene
TAS1R3
Location
Chr 11,334,174 (GRCh38)
Highest magnitude
2.6Worth knowing
Tested on
23andMe
Minor allele frequency
4%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodcommon in complete genomicsTypical · 0.0
  2. C;TGoodextra tasting ability?Worth knowing · 2.4
  3. T;TMost notableGoodextra tasting ability?Worth knowing · 2.6

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other TAS1R3 SNPs

All TAS1R3 SNPs

Notes

From SNPedia

Notes

Influences tasting ability. This blog entry discusses the research. the rare T allele of rs307377(T) (R757C) in TAS1R3 led to a doubling of umami ratings of 25 mmol MPG/L. Other suggestive SNPs of TAS1R3 include the A allele of A5T and the A allele of R247H, which both resulted in an approximate doubling of umami ratings of 200 mmol MPG/L

C;T

rare T allele, better at detecting umami (うま味) taste

T;T

rare T allele, better at detecting umami taste

Source and license

Adapted from rs307377 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.