rs3095318
A SNP in the CDSN gene on chromosome 6. Its most notable genotype is A;T: In Japanese populations, associated with HLA-B*5801 allele and allopurinol side effects
- Gene
- CDSN
- Location
- Chr 631,120,368 (GRCh38)
- Highest magnitude
- 3.0Important
- Tested on
- 23andMe
- Minor allele frequency
- 12%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- T;TGoodcommon/normal
- A;TMost notableBadIn Japanese populations, associated with HLA-B*5801 allele and allopurinol side effects
- A;ABadIn Japanese populations, associated with HLA-B*5801 allele and allopurinol side effects
SNPedia records rs3095318 on the minus strand: (A;A), (A;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Genosets
- Gs187HLA-B*5801 homozygosity is possible. too common to be usefulWorth knowing
- Gs186HLA-B*5801 heterozygosity is possible, unfortunately this is just too common to be usefulMinor
Genosets combine several genotypes. Twofold checks them in your report.
Notes
From SNPedia
Notes
The minor allele rs3095318(T), as defined on the minus strand, is reported to be associated in Japanese populations with the HLA-B*5801 allele and therefore susceptibility to severe side effects from taking allopurinol and perhaps other drugs. Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene.
A;T
see discussion at rs3095318
A;A
see discussion at rs3095318
Source and license
Adapted from rs3095318 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.