rs312481

A SNP in the CACNA1D gene on chromosome 3. Its most notable genotype is G;G: better response to certain calcium channel blockers

Gene
CACNA1D
Location
Chr 353,517,875 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
18%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableGoodbetter response to certain calcium channel blockersTypical · 0.068% of people
  2. A;GNot ratednormalTypical · 0.028% of people
  3. A;ANot ratednormalTypical · 0.03% of people

SNPedia records rs312481 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageG;G 68% A;G 28% A;A 3%
  • European ancestry (Utah)G;G 54% A;G 39% A;A 7%
  • Han Chinese (Beijing)G;G 66% A;G 31% A;A 3%
  • Japanese (Tokyo)G;G 80% A;G 19% A;A <1%
  • Yoruba (Nigeria)G;G 80% A;G 18% A;A 2%
  • African ancestry (Southwest US)G;G 82% A;G 14% A;A 4%
  • Gujarati IndianG;G 69% A;G 26% A;A 5%
  • Luhya (Kenya)G;G 72% A;G 22% A;A 6%
  • Mexican ancestry (Los Angeles)G;G 56% A;G 42% A;A 2%
  • Maasai (Kenya)G;G 70% A;G 27% A;A 3%
  • TuscanG;G 52% A;G 47% A;A 2%

Other CACNA1D SNPs

All CACNA1D SNPs

Notes

From SNPedia

Notes

rs312481 is a SNP in the calcium channel, voltage-dependent, L type, alpha 1D subunit CACNA1D gene. A study of 161 Japanese patients (85 men, 76 women) being treated for hypertension with L-type dCCBs (calcium channel blockers) concluded that individuals with rs312481(C;C) genotypes responded better, as measured by lowered systolic and diastolic blood pressure readings.

Source and license

Adapted from rs312481 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.