rs3774426

A SNP in the CACNA1D gene on chromosome 3. Its most notable genotype is C;C: better response to certain calcium channel blockers

Gene
CACNA1D
Location
Chr 353,524,975 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
26%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodbetter response to certain calcium channel blockersTypical · 0.063% of people
  2. C;TNot ratednormalTypical · 0.029% of people
  3. T;TNot ratednormalTypical · 0.08% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageC;C 63% C;T 29% T;T 8%
  • European ancestry (Utah)C;C 35% C;T 46% T;T 19%
  • Han Chinese (Beijing)C;C 64% C;T 29% T;T 7%
  • Japanese (Tokyo)C;C 74% C;T 23% T;T 2%
  • Yoruba (Nigeria)C;C 78% C;T 19% T;T 3%

Other CACNA1D SNPs

All CACNA1D SNPs

Notes

From SNPedia

Notes

rs3774426 is a SNP in the calcium channel, voltage-dependent, L type, alpha 1D subunit CACNA1D gene. A study of 161 Japanese patients (85 men, 76 women) being treated for hypertension with L-type dCCBs (calcium channel blockers) concluded that individuals with rs3774426(C;C) genotypes responded better, as measured by lowered systolic and diastolic blood pressure readings.

Source and license

Adapted from rs3774426 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.