rs3129878(A;C)

1.36 slightly higher risk for infertility in Chinese men

Magnitude
1.2Minor
Repute
Bad
Frequency
40%Average of 11 populations
On SNPedia
rs3129878(A;C)
Gene
HLA-DRA

Frequency

Share of people with A;C in each HapMap population.

  • Japanese (Tokyo)52%
  • Maasai (Kenya)51%
  • Han Chinese (Beijing)45%
  • European ancestry (Utah)41%
  • Chinese (Denver)39%
  • African ancestry (Southwest US)39%
  • Mexican ancestry (Los Angeles)38%
  • Gujarati Indian35%
  • Tuscan34%
  • Yoruba (Nigeria)32%
  • Luhya (Kenya)31%

Other genotypes of rs3129878

  1. A;AGoodnormal risk for infertility in Chinese menTypical · 0.049% of people
  2. C;CMost notableBad>1.36 higher risk for infertility in Chinese menMinor · 1.311% of people

All about rs3129878

Notes

From SNPedia

A 2012 study of Han Chinese men showed slightly increased risk (odds ratio 1.32) for nonobstructive azoospermia (very low sperm count) and thus infertility for the rarer rs3129878(C) SNP.

Source and license

Adapted from rs3129878(A;C) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.