rs3129878

A SNP in the HLA-DRA gene on chromosome 6. Its most notable genotype is C;C: >1.36 higher risk for infertility in Chinese men

Gene
HLA-DRA
Location
Chr 632,440,958 (GRCh38)
Highest magnitude
1.3Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
31%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodnormal risk for infertility in Chinese menTypical · 0.049% of people
  2. A;CBad1.36 slightly higher risk for infertility in Chinese menMinor · 1.240% of people
  3. C;CMost notableBad>1.36 higher risk for infertility in Chinese menMinor · 1.311% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 49% A;C 40% C;C 11%
  • European ancestry (Utah)A;A 56% A;C 41% C;C 4%
  • Han Chinese (Beijing)A;A 43% A;C 45% C;C 12%
  • Japanese (Tokyo)A;A 22% A;C 52% C;C 26%
  • Yoruba (Nigeria)A;A 61% A;C 32% C;C 7%
  • African ancestry (Southwest US)A;A 53% A;C 39% C;C 9%
  • Chinese (Denver)A;A 53% A;C 39% C;C 7%
  • Gujarati IndianA;A 56% A;C 35% C;C 9%
  • Luhya (Kenya)A;A 51% A;C 31% C;C 18%
  • Mexican ancestry (Los Angeles)A;A 48% A;C 38% C;C 14%
  • Maasai (Kenya)A;A 37% A;C 51% C;C 12%
  • TuscanA;A 58% A;C 34% C;C 8%

Conditions, medicines and genes

Other HLA-DRA SNPs

All HLA-DRA SNPs

Notes

From SNPedia

Notes

rs3129878 is a SNP in the HLA gene region. It has been associated with slightly (~30%) higher risk for azoospermia (lack of sperm) and thus male infertility in both Chinese and Japanese men.

A;C

A 2012 study of Han Chinese men showed slightly increased risk (odds ratio 1.32) for nonobstructive azoospermia (very low sperm count) and thus infertility for the rarer rs3129878(C) SNP.

C;C

A 2012 study of Han Chinese men showed slightly increased risk (odds ratio 1.32) for nonobstructive azoospermia (very low sperm count) and thus infertility for the rarer rs3129878(C) SNP.

Source and license

Adapted from rs3129878 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.