rs7192
A SNP in the HLA-DRA gene on chromosome 6. Its most notable genotype is T;T: 3x higher risk for developing a peanut allergy
- Gene
- HLA-DRA
- Location
- Chr 632,443,869 (GRCh38)
- Highest magnitude
- 3.0Important
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 37%
Genotypes
As shown in 23andMe and AncestryDNA files.
- G;GGoodcommon/normal
- G;TBad1.7x increased risk for developing a peanut allergy
- T;TMost notableBad3x higher risk for developing a peanut allergy
On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageG;G 44% G;T 42% T;T 14%
- European ancestry (Utah)G;G 46% G;T 42% T;T 13%
- Han Chinese (Beijing)G;G 51% G;T 38% T;T 11%
- Japanese (Tokyo)G;G 33% G;T 50% T;T 18%
- Yoruba (Nigeria)G;G 33% G;T 46% T;T 20%
- African ancestry (Southwest US)G;G 42% G;T 37% T;T 21%
- Chinese (Denver)G;G 59% G;T 34% T;T 7%
- Gujarati IndianG;G 60% G;T 37% T;T 3%
- Luhya (Kenya)G;G 34% G;T 48% T;T 18%
- Mexican ancestry (Los Angeles)G;G 41% G;T 43% T;T 16%
- Maasai (Kenya)G;G 39% G;T 46% T;T 15%
- TuscanG;G 43% G;T 43% T;T 14%
Related
Notes
From SNPedia
Show notes, about 130 words
rs7192, also known as Leu242Val or L242V, is a SNP in the HLA-DRA gene on chromosome 6. A study of several thousand children and their parents, most with food allergies, concluded that two SNPs, rs7192 and rs9275596, are associated with increased susceptibility to developing a peanut allergy in populations of European ancestry. The odds ratio reported for rs7192(T) were 1.7 (p=10e-8). Detecting significant single-nucleotide polymorphisms in a rheumatoid arthritis study using random forests
G;T
In populations of European ancestry, the rs7192(T) allele is associated with somewhat increased risk for developing peanut allergies.
T;T
In populations of European ancestry, each copy of a rs7192(T) allele is reported to increase risk for developing a peanut allergy by 1.7x.
Source and license
Adapted from rs7192 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.