rs3135391(A;A)

3 to 6 fold higher risk for multiple sclerosis

Magnitude
3.0Important
Repute
Bad
Frequency
<1%Average of 11 populations
On SNPedia
rs3135391(T;T)Minus strand
Gene
HLA-DRA

Frequency

Share of people with A;A in each HapMap population.

  • European ancestry (Utah)4%
  • Tuscan1%
  • Han Chinese (Beijing)0%
  • Japanese (Tokyo)0%
  • Yoruba (Nigeria)0%
  • African ancestry (Southwest US)0%
  • Chinese (Denver)0%
  • Gujarati Indian0%
  • Luhya (Kenya)0%
  • Mexican ancestry (Los Angeles)0%
  • Maasai (Kenya)0%

Other genotypes of rs3135391

  1. G;GGoodnormalTypical · 0.091% of people
  2. A;GBadHLA-DRB1*1501 carrier; higher multiple sclerosis riskWorth knowing · 2.09% of people

All about rs3135391

Notes

From SNPedia

Rs3135391(T;T) is highly correlated with the HLA-DRB1*1501 allele. There is 3-6x higher risk of multiple sclerosis associated with the (T;T) genotype.

Source and license

Adapted from rs3135391(T;T) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.