rs3135391(A;G)

HLA-DRB1*1501 carrier; higher multiple sclerosis risk

Magnitude
2.0Worth knowing
Repute
Bad
Frequency
9%Average of 11 populations
On SNPedia
rs3135391(C;T)Minus strand
Gene
HLA-DRA

Frequency

Share of people with A;G in each HapMap population.

  • European ancestry (Utah)29%
  • Tuscan15%
  • African ancestry (Southwest US)12%
  • Mexican ancestry (Los Angeles)12%
  • Yoruba (Nigeria)7%
  • Luhya (Kenya)6%
  • Maasai (Kenya)5%
  • Gujarati Indian4%
  • Han Chinese (Beijing)4%
  • Chinese (Denver)<1%
  • Japanese (Tokyo)0%

Other genotypes of rs3135391

  1. G;GGoodnormalTypical · 0.091% of people
  2. A;AMost notableBad3 to 6 fold higher risk for multiple sclerosisImportant · 3.0<1% of people

All about rs3135391

Notes

From SNPedia

Rs3135391(C;T) is highly correlated with the HLA-DRB1*1501 allele. There is a 3x higher risk of multiple sclerosis associated with the (C;T) genotype.

Source and license

Adapted from rs3135391(C;T) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.