rs3135506

A SNP in the APOA5 gene on chromosome 11. Its most notable genotype is G;G: common on affy axiom data

Gene
APOA5
Location
Chr 11116,791,691 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
5%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableGoodcommon on affy axiom dataTypical · 0.095% of people

On SNPedia: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageG;G 95%
  • European ancestry (Utah)G;G 88%
  • Han Chinese (Beijing)G;G 100%
  • Japanese (Tokyo)G;G 100%
  • Yoruba (Nigeria)G;G 92%

Conditions, medicines and genes

Other APOA5 SNPs

All APOA5 SNPs

Notes

From SNPedia

Notes

Rs3135506 (also known as S19W) is associated with severe hypertriglyceridemia. 132 patients of European ancestry with severe HTG (fasting plasma TG>10 mmol/L), and 351 matched normolipidemic controls. It is discussed in ; however, the SNP that prevents weight gain from high fat diets is rs662799.

G;G

appears to be common on the 23andMe platform

Source and license

Adapted from rs3135506 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.