rs662799

A SNP in the APOA5 gene on chromosome 11. Its most notable genotype is A;G: 1.4x higher early heart attack risk; less weight gain on high fat diets

Gene
APOA5
Location
Chr 11116,792,991 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
15%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodnormalTypical · 0.067% of people
  2. A;GMost notableBad1.4x higher early heart attack risk; less weight gain on high fat dietsWorth knowing · 2.030% of people
  3. G;GBad2x higher early heart attack risk; less weight gain on high fat dietsWorth knowing · 2.03% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageA;A 67% A;G 30% G;G 3%
  • European ancestry (Utah)A;A 97% A;G 3% G;G 0%
  • Han Chinese (Beijing)A;A 51% A;G 44% G;G 4%
  • Japanese (Tokyo)A;A 47% A;G 49% G;G 5%
  • Yoruba (Nigeria)A;A 75% A;G 24% G;G 2%

Conditions, medicines and genes

Other APOA5 SNPs

All APOA5 SNPs

Notes

From SNPedia

Notes

rs662799 is a SNP in the APOA5 gene. The rarer rs662799(C) allele has been associated in multiple reports (cited below) to be associated with higher triglyceride levels. Independently of triglyceride levels, perhaps, a study based on 1,864 Italian patients C in modulates the effect of fat intake on BMI and obesity risk in both men and women. Individuals with at least one C allele gained significantly less weight on a high fat diet than those homozygous for the T allele. rs662799 (-1131T>C) influences severe hypertriglyceridemia. 132 patients of European ancestry with severe HTG (fasting plasma TG>10 mmol/L), and 351 matched controls Response to Diet and Exercise

Source and license

Adapted from rs662799 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.