rs3218253
A SNP in the IL2RB gene on chromosome 22. Its most notable genotype is G;G: common/normal
- Gene
- IL2RB
- Location
- Chr 2237,148,770 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 17%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- G;GMost notableGoodcommon/normal
- A;GBadT allele is a minor risk factor associated with rheumatoid arthritis
- A;ABadSlight association with rheumatoid arthritis
SNPedia records rs3218253 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageG;G 77% A;G 21% A;A 2%
- European ancestry (Utah)G;G 64% A;G 32% A;A 5%
- Han Chinese (Beijing)G;G 78% A;G 22% A;A 0%
- Japanese (Tokyo)G;G 91% A;G 9% A;A 0%
- Yoruba (Nigeria)G;G 78% A;G 21% A;A 2%
Related
Notes
From SNPedia
Notes
A;G
See rs3218253
A;A
See rs3218253
Source and license
Adapted from rs3218253 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.